Emamectin Benzoate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Emamectin Benzoate 通过结合 γ-氨基丁酸 (GABA) 受体和谷氨酸门控氯离子通道，扰乱节肢动物内的神经信号，充当氯离子通道激活剂。

Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.

Cell Viability AssayCell Line:human normal bronchial epithelial cell line 16HBE Concentration:2.5, 5, 7.5,10,15, 20, 40 μM Incubation Time:12 and 24 hoursResult:Decreased cell viability in a time- and dose-dependent manner wirh IC50s of 11.88 μM and 9.67 μM in 12 and 24 hours, respectively.Apoptosis AnalysisCell Line:human normal bronchial epithelial cell line 16HBE Concentration:2.5, 5, 10, 20 μM Incubation Time:24 hours Result:Induced apoptosis and caused chromatin shrinkage and nuclear fragmentation.Western Blot Analysis Cell Line:human normal bronchial epithelial cell line 16HBE Concentration:2.5, 5, 10, 20 μM Incubation Time:12 hours Result:Increased the amounts of cytochrome-c, caspase-3, cas-pase-9, cleaved-PARP, Bax/Bcl-2.

Animal Model:10 weeks old Swiss albino male mice (25-30 g)Dosage:25, 50, 100 mg/kg Administration:Oral; daily; for 14 days Result:Caused a marked induction of oxidative damage in liver tissue as demonstrated by an increased level of TBARS and reduced GSH level.

MK-244

Membrane Transporter/Ion Channel

Other Targets

GABA Receptor

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155569-91-8

1880.33

C104H154N2O28

>98% (HPLC)

DMSO:31 mg/mL (16.49 mM)

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(-20℃)

With Ice Pack

≥ 2 years